Tuesday, April 9, 2013

HP Moonshot server class leaves concept, to power commercial-grade internet of the future

HP Moonshot server class leaves concept, to power commercialgrade internet of the future

We're all about the future of the internet here at Engadget, so you can imagine our excitement when HP today announced that it's shooting for the moon with its latest server system, the HP Moonshot. Promising significantly reduced energy consumption and space requirements, the Moonshot is HP's "second generation" server tech, and it's intended for use with "social, cloud, mobile, and big data," according to the company. In so many words, this is HP's attempt to get out ahead of where it sees internet use going -- it was first unveiled in concept form last summer, but now it's apparently ready for primetime. A video of the new tech getting introduced is just beyond the break.

Said servers are rolling out in 2013's latter half, and can be tailored to a clients' needs with specs from a variety of internals providers (AMD, AppliedMicro, Calxeda, Intel, and Texas Instruments are all specifically named by HP). All of this amounts to one thing: the information superhighway of tomorrow is being paved today, and we can't wait to take a spin. Here's hoping there'll still be plenty of stupid gifs.

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Source: http://www.engadget.com/2013/04/09/hp-moonshot-official/

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Monday, April 8, 2013

Intermittent treatment with vemurafenib may prevent lethal drug resistance in melanoma

Apr. 7, 2013 ? Vemurafenib-resistant tumors in patients with melanoma showed reduced growth after cessation of treatment, and in animal models, drug resistance was prevented by intermittent treatment, according to data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10.

"It was exciting to witness the discovery of BRAF mutations in melanoma and the translation of this discovery into an effective therapy with vemurafenib," said Darrin Stuart, Ph.D., senior research investigator at the Novartis Institutes for Biomedical Research in Emeryville, Calif. "It was, however, disappointing to see patients stop responding to such a promising therapy after six to eight months of treatment."

BRAF mutations are found in more than half of all cases of melanoma, and previous studies have shown vemurafenib increases survival for these patients, according to Stuart. However, most patients relapse with lethal, drug-resistant disease.

In a previous study to investigate the mechanisms causing melanomas to become resistant to vemurafenib, Stuart and his colleagues grew patient-derived tumors expressing BRAF mutations in mice and demonstrated that not only do these tumors develop vemurafenib resistance, but they become dependent on the drug to grow. Tumors stopped growing and regressed after cessation of the drug in these animals.

To evaluate whether the drug dependency observed in animals is seen in humans as well, Stuart and his team collaborated with colleagues who evaluated 42 patients with vemurafenib-resistant tumors at the Royal Marsden Hospital in London, United Kingdom. Computed tomography scans of the tumors taken after cessation of treatment were available for 19 patients. Of these patients, 14 showed a decrease in the rate of their tumor growth.

"This is the first evidence that the drug-addicted state that we observed in our mouse models may also occur in humans," said Stuart.

He and his colleagues also implanted mice with human patient-derived tumors and treated them with vemurafenib either continuously or intermittently -- four weeks on and two weeks off. They found that none of the tumors in animals assigned to intermittent dosing developed drug resistance.

"Continuous dosing maintained the selective pressure required for the few surviving tumor cells to develop resistance, and alternating the selective pressure through intermittent dosing appeared to prevent the evolution and expansion of resistant cells," said Stuart. "This study provides insight into how vemurafenib-resistant tumors evolve. Alternative dose regimens could prolong the durability of response to vemurafenib in BRAF-mutant melanoma."

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The above story is reprinted from materials provided by American Association for Cancer Research (AACR).

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/VxAgGzoGWXM/130407183553.htm

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Sunday, April 7, 2013

PFT: Revis not optimistic about trade possibilities

nfl_g_cantu_gb1_300Getty Images

There?s a common belief that the pending concussion litigation against the NFL ultimately will result only in the lawyers making money.

The so-called expert witnesses likely will, too.

Often overlooked in complex litigation involving esoteric medical knowledge and jargon is the fact that the men and women who have the education and experience to share that knowledge and jargon with a judge and a jury get paid a lot of money.

That reality routinely results in a blurring of ethical lines.? According to Steve Fainaru and Mark Fainaru-Wada of ESPN.com, Dr. Robert Cantu previously served as a senior adviser to the NFL?s Head, Neck and Spine committee ? but he also has consulted with the lawyers who are suing the NFL on behalf of thousands of former players.

?It was an informational session, just like I get paid to give a talk someplace else,? Cantu said of a February 2012 presentation to the lawyers representing the players.? He also justified working for the players suing the league by explaining that the NFL could hire him to serve as an expert witness, which would block from him talking to those suing the league.

?If [the NFL] wanted to put me on their payroll, to defend their case, then I?m not gonna say boo about those issues [to the plaintiffs],? said Cantu, who gets $800 per hour for legal services, $5,000 for depositions, and $8,000 per day for trial testimony.

Cantu?s attitude underscores one of the biggest problems with the litigation industry.? Many experts aren?t necessarily motivated by the pursuit of justice but by the supplementation of their total income with the exorbitant fees they charge.? And since there?s plenty of discretion to be exercised when telling the truth, their testimony often can be molded to help whichever side of a case hires them first.

Here?s a concrete example, for those of you who are still awake.

Eleven years ago, I represented a former employee of a major U.S. low-cost big-box retailer who had been forced to take an alcohol test under circumstances that, as the jury concluded, didn?t justify an invasion of the employee?s privacy rights via the drawing of a blood sample.? The case included testimony from an expert witness who had been hired by the employer to justify the conclusion, based on the blood-alcohol concentration measured by the test, that the employee had indeed been intoxicated at work.

On cross-examination, I confronted the expert witness with a passage from a written report on the issue of blood-alcohol testing.? In the report, the author expressed concern about the reliability of efforts to use blood-alcohol measurements to determine a person?s BAC at an earlier point in time.

I read the sentence to the expert witness, and I asked the expert witness if he agreed with the statement.

He said, ?No.?

So I read it to him again, slowly.? I asked him if he agreed with that statement.

Again, he said, ?No.?

So I handed him the report, showed him the first page of it, and asked him to tell the judge and the jury who had written the report.

The expert witness, after taking a gulp, said his own name.

And that?s pretty much all I ever needed to know about the world of expert witnesses.

Source: http://profootballtalk.nbcsports.com/2013/04/05/revis-not-optimistic-trade-gets-done/related/

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World powers and Iran at a stalemate

After two days of talks over Tehran's nuclear program, the EU foreign policy chief said Iran and world powers remained far apart. A breakthrough deal will not be on the table.

By Justyna Pawlak and Yeganeh Torbati,?Reuters / April 6, 2013

Iran's chief negotiator Saeed Jalili attends a news conference after the talks on Iran's nuclear programme in Almaty, April 6. World powers and Iran remained far apart after ending two days of intensive talks on Tehran's nuclear programme on Saturday, prolonging a stand-off that risks spiralling into a new Middle East war.

Shamil Zhumatov/Reuters

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World powers and Iran remained far apart after ending two days of intensive talks on?Tehran's nuclear program on Saturday, the?European Union's foreign policy chief said, prolonging a stand-off that risks spiralling into a new?Middle East?war.

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The failure to reach a breakthrough deal aimed at easing growing international concern over Iran's contested nuclear activity marked a further setback for diplomatic efforts to resolve the decade-old dispute peacefully.

Underlining the lack of substantial progress during the meeting in the Kazakh city of?Almaty, no new negotiations between the two sides appeared to have been scheduled.

"Over two days of talks, we had long and intensive discussions on the issues addressed in our confidence-building proposal," EU foreign policy chief?Catherine Ashton?said.

"It became clear that our positions remain far apart," Ashton, who represents the six powers - the?United States,?Russia,?China,?France, Britain and?Germany?- in dealings with Iran, told a news conference.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/DHG5y47GU94/World-powers-and-Iran-at-a-stalemate

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Saturday, April 6, 2013

U.N. rights chief calls for closure of Guantanamo prison

By Stephanie Nebehay

GENEVA (Reuters) - The U.N. human rights chief called on the United States on Friday to close down the Guantanamo prison camp, saying the indefinite imprisonment of many detainees without charge or trial violated international law.

Navi Pillay said the hunger strike being staged by some inmates at the Guantanamo Bay U.S. Naval Base in southeastern Cuba was a "desperate act" but "scarcely surprising".

"We must be clear about this: the United States is in clear breach not just of its own commitments but also of international laws and standards that it is obliged to uphold," the United Nations High Commissioner for Human Rights said in a statement.

U.S. President Barack Obama pledged four years ago to close the controversial facility, opened by the Bush administration in January 2002 to hold men captured in counter-terrorism operations after the deadly September 11 attacks on America.

Pillay voiced deep disappointment at the U.S. government's failure to close Guantanamo despite its repeated commitments, but welcomed comments by a White House spokesman last week reiterating the intention to do so while citing congressional legislation as the prime obstacle.

About half of the current 166 detainees have been cleared for transfer either to home countries or third countries for resettlement, Pillay said. "As a first step, those who have been cleared for release must be released," she said.

"FESTERING FOR MORE THAN A DECADE"

"Others reportedly have been designated for further indefinite detention. Some of them have been festering in this detention center for more than a decade," she said.

Guantanamo detainees accused of crimes should be tried in civilian courts, especially as the military commissions "do not meet international fair trial standards" despite improvements since 2009, said Pillay, a former U.N. war crimes judge.

Of the 166 remaining detainees, only nine have been charged or convicted of crimes, according to military records. The 166 detainees are from 23 countries, the Red Cross says.

Forty inmates are currently staging a hunger strike to protest against their indefinite detention, according to a U.S. military spokesman at Guantanamo. Some have lost so much weight that they are being force-fed liquid nutrients through tubes inserted into their noses and down into their stomachs.

The International Committee of the Red Cross has visited Guantanamo regularly since it opened to check on conditions of detention and ensure humane treatment. It is currently carrying out its 93rd visit, expected to last another week.

The ICRC sent a doctor and another delegate to Guantanamo on March 25, a week earlier than planned because of concern about a growing hunger strike among detainees, the humanitarian agency said at the time.

An ICRC team of 13 now there are discussing issues including the hunger strike separately with authorities and in private interviews with inmates, ICRC spokesman Alexis Heeb said.

"Detainees can raise any problem they want to bring to our attention, this can be issues of detention, Koran issues, requests for medical attention," Heeb told Reuters on Friday, referring to media reports about searches of Korans for contraband.

The ICRC has a clear position of being opposed to forced feeding or forced treatment and upholds the principle of leaving the right to detainees to choose his or her fate, he said.

ICRC President Peter Maurer is expected to raise concerns about Guantanamo in talks next week with senior U.S. officials during his three-day visit to Washington, Heeb said.

"We continue to hold detainees under the internationally recognized Law of War and in keeping with the best of our core values, safeguarding and humanely treating all who are in our care and custody, there. Assertions that present some alternate narrative simply do not withstand intellectual rigor," a U.S. Department of Defense spokesman, Lieutenant Colonel Todd Breasseale, told Reuters in response to Pillay's statement.

(Reporting by Stephanie Nebehay in Geneva; Additional reporting by Jane Sutton in Miami; Editing by Pravin Char and Stephen Powell)

Source: http://news.yahoo.com/u-n-rights-boss-calls-closure-guantanamo-prison-140410982.html

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The HSUS Honors Indiana Prosecutor with Award For Animal ...

April?5,?2013

  • Judge Marianne Vorhees cited the terrible injuries of "Wonder" during Johnson's sentencing hearing. Linda Turner

  • "I named the dog 'Wonder,' because it is a wonder that he had any affection to give," said animal behaviorist James Turner. "He and I bonded in the short time we had together." Linda Turner

The Humane Society of the United States honored Delaware County Deputy Prosecutor Joe E. Orick, of Muncie, Ind., with the Prosecutor Recognition Award, for successfully prosecuting Rahsaan A. Johnson for dogfighting-related charges.

Specifically, Johnson was convicted of 14 counts of possessing an animal for use in an animal fighting contest and seven counts of cruelty to an animal.

Johnson was sentenced last month to the maximum four-year executed sentence to the Indiana Department of Corrections.

Sherry Ramsey, director of animal cruelty prosecutions for The HSUS said: "The Humane Society of the United States is pleased to have been able to support Prosecutor Orick in his steadfast dedication to provide justice for the abused dogs in this case. We need more determined prosecutors like Prosecutor Orick. We are also extremely grateful to Judge Marianne Vorhees for taking these crimes seriously."

Orick said: "The successful prosecution of this case was made as a direct result of the tremendous support that I received from Sherry Ramsey and The Humane Society of the United States."

This case was a long-fought victory for Orick, who utilized The HSUS's prosecutor resources program for help with legal research on various issues of law. The HSUS has a long history of collaborating with and training prosecutors around the country in achieving effective results in animal cruelty cases. Learn more about the available resources here.

Background:

  • Authorities were alerted to Johnson's possible dogfighting activity in March 2012, when two dogs in poor shape arrived at the Indianapolis Airport from the Dominican Republic. U.S. Customs officials notified local law enforcement that the animals appeared underweight, sickly and covered with scars that looked to be from bite wounds.
  • The Muncie Police department obtained a search warrant for Johnson?s property. There, they found 25 dogs, many without access to food or water, along with reported treadmills, weighted collars, Penicillin, wound spray, syringes, shock collars and other items commonly associated with dogfighting. Johnson was arrested on April 5, 2012.
  • The jury found Johnson guilty on Nov. 5, 2012.
  • In determining the sentence, Judge Marianne Vorhees noted the particularly disturbing condition of a dog named Wonder, who had to be euthanized when he was found to be suffering a severe infection as the result of numerous, open puncture wounds along his jawline and face. She went on to note the defendant's refusal to take any responsibility for his conduct and called dogfighting a "brutal and disgusting" activity. Johnson is still free pending appeal.

Media Contact: Stephanie Twining, 301-258-1491, stwining@humanesociety.org

Source: http://www.humanesociety.org/news/press_releases/2013/04/indiana-prosecutor-awarded-fighting-cruelty-040513.html

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Friday, April 5, 2013

AK Steel union leader hopes to face Boehner for House seat

A steelworker and union official who introduced President Barack Obama at a campaign rally seven months ago introduced himself Friday as a Democratic candidate in House Speaker John Boehner's western Ohio district.

Andrew Hounshell, 37, planned a kickoff announcement Friday evening in Middletown, after earlier revealing a campaign website and Twitter account for his 2014 campaign.

"We learn from our mistakes, and one of those is that we know now that voting the same way over and over and expecting our leaders in Washington to start paying attention to the families in their districts instead of the lobbyists in their golf carts isn't going to happen," Hounshell said in a statement.

Hounshell is vice president of the International Association of Machinists and Aerospace Workers local that represents hourly employees at AK Steel's Middletown plant. That union began representing the Middletown workers in 2006 amid a company lockout that lasted more than a year.

He gave a speech introducing President Barack Obama at a September rally in Cincinnati's Eden Park, but this will be his first run for public office. The Middletown native says he served in the Army out of high school before going to work at AK Steel, and that he is studying for a degree in labor studies. He and his wife have 3-year-old triplets.

David Kern, Republican Party chairman in Boehner's home Butler County, said Hounshell joins others who "have jousted at windmills" in the district.

"Congressman Speaker Boehner has done a superb job representing the district, and he has stellar ratings on issues like fiscal conservatism and from organizations like the NRA and Right to Life that mean a lot to people in our area," Kern said.

Boehner won the Republican-dominated 8th District in 1990 after his GOP primary victory over an incumbent caught in a sex scandal, and he has handily won re-elections since. Boehner, who usually spends much of the campaign season speaking and raising money for other Republican candidates, won nearly 66 percent of the vote in the 2010 general election and had no Democratic opponent last year.

The district begins just south of the 63-year-old Boehner's West Chester Township home and stretches north along the Indiana border to near Celina in northwest Ohio, and eastward through Springfield and Clark County.

Source: http://www.wlwt.com/news/politics/AK-Steel-union-leader-hopes-to-face-Boehner-for-House-seat/-/9837768/19633070/-/dtuu3vz/-/index.html?absolute=true

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